abstract：:Amongst the various types of cancer, breast cancer is a highly heterogeneous disease and known as the leading cause of death among women globally. The extensive interdisciplinary investigation in nanotechnology and cancer biomedical research has been evolved over the years for its effective treatment. However, the adv...

journal_title：Seminars in cancer biology

authors： Afzal M,Ameeduzzafar,Alharbi KS,Alruwaili NK,Al-Abassi FA,Al-Malki AAL,Kazmi I,Kumar V,Kamal MA,Nadeem MS,Aslam M,Anwar F

更新日期：2019-12-20 00:00:00

abstract：:Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...

journal_title：Seminars in cancer biology

authors： Motegi A,Masutani M,Yoshioka KI,Bessho T

更新日期：2019-10-01 00:00:00

abstract：:Large-scale sequencing methodologies have helped us identify numerous genomic alterations and we have started to scratch the surface of many new targets for treatment of cancer and the associated predictive biomarkers. TRAIL (TNF-related apoptosis-inducing ligand) is a highly appreciated anti-cancer molecule because o...

journal_title：Seminars in cancer biology

authors： Fayyaz S,Javed Z,Attar R,Farooqi AA,Yaylim I,Ahmad A

更新日期：2019-10-01 00:00:00

abstract：:Intellectual property documents (patents and their published applications) are not only collections of legal exclusivity claims but also repositories of scientific and technical information, even though they are not peer reviewed. We have identified and analyzed international disclosures concerning drug repurposing fo...

journal_title：Seminars in cancer biology

authors： Mucke HAM

更新日期：2019-09-20 00:00:00

abstract：:Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activ...

journal_title：Seminars in cancer biology

authors： Aiello P,Consalvi S,Poce G,Raguzzini A,Toti E,Palmery M,Biava M,Bernardi M,Kamal MA,Perry G,Peluso I

更新日期：2019-08-24 00:00:00

abstract：:Cancer, being the most prevalent and resistant disease afflicting any gender, age or social status, is the ultimate challenge for the scientific community. The new generation therapeutics for cancer management has shifted the approach to personalized/precision medicine, making use of patient- and tumor-specific marker...

journal_title：Seminars in cancer biology

authors： Zafar S,Beg S,Panda SK,Rahman M,Alharbi KS,Jain GK,Ahmad FJ

更新日期：2019-08-20 00:00:00

abstract：:Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying have not been fully elucidated. As a family of NAD+ dependent protein modifying enzymes, sirtuins...

journal_title：Seminars in cancer biology

authors： Zhu S,Dong Z,Ke X,Hou J,Zhao E,Zhang K,Wang F,Yang L,Xiang Z,Cui H

更新日期：2019-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer related-deaths. The risk of development of CRC is complex and multifactorial, and includes disruption of homeostasis of the intestinal epithelial layer mediated though dysregulations of tumor suppressing/promoting signaling pathways. Guanylate cyclase 2C (...

journal_title：Seminars in cancer biology

authors： Yarla NS,Gali H,Pathuri G,Smriti S,Farooqui M,Panneerselvam J,Kumar G,Madka V,Rao CV

更新日期：2019-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a result, accumulated evidence of MMPs incriminating role has m...

journal_title：Seminars in cancer biology

authors： Alaseem A,Alhazzani K,Dondapati P,Alobid S,Bishayee A,Rathinavelu A

更新日期：2019-06-01 00:00:00

abstract：:Angiogenesis plays a pivotal role in cancer progression and is required for tissue invasion and metastasis. Starting with Folkman's initial observations in 1971, basic research continued to shed new molecular insight into this multifaceted process, leading to the development of several anti-angiogenic drugs. To date, ...

journal_title：Seminars in cancer biology

authors： Ricciuti B,Foglietta J,Bianconi V,Sahebkar A,Pirro M

更新日期：2019-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical challenge for optimization of treatment modalities in reducing the morbidity and mortality associated with this disease. A more precise under...

journal_title：Seminars in cancer biology

authors： Wang W,Kandimalla R,Huang H,Zhu L,Li Y,Gao F,Goel A,Wang X

更新日期：2019-04-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, comprising approximately 75% of all kidney tumors. Recent the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) studies have significantly advanced the molecular characterization of RCC and facilitated the deve...

journal_title：Seminars in cancer biology

authors： Li QK,Pavlovich CP,Zhang H,Kinsinger CR,Chan DW

更新日期：2019-04-01 00:00:00

abstract：:Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its regulators, most frequent in human cancers, are the main force for incessant RAS activation and as...

journal_title：Seminars in cancer biology

authors： Khan AQ,Kuttikrishnan S,Siveen KS,Prabhu KS,Shanmugakonar M,Al-Naemi HA,Haris M,Dermime S,Uddin S

更新日期：2019-02-01 00:00:00

abstract：:Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using peptidomimetics were successful in cell culture but failed spectacularly in clinical trials, making indus...

journal_title：Seminars in cancer biology

authors： Mott HR,Owen D

更新日期：2019-02-01 00:00:00

abstract：:We have recently shown that natural killer (NK) cells select and differentiate cancer stem cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) and TNF-alpha (TNF-α), preventing tumor growth and inducing remodeling of the tumor microenvironment. Since many conventional therapeutic str...

journal_title：Seminars in cancer biology

authors： Jewett A,Kos J,Fong Y,Ko MW,Safaei T,Perišić Nanut M,Kaur K

更新日期：2018-12-01 00:00:00

abstract：:Cancer-testis antigens (CTAs) are considered as unique and promising cancer biomarkers and targets for cancer therapy. CTAs are multifunctional protein group with specific expression patterns in normal embryonic and adult cells and various types of cancer cells. CTAs are involved in regulating of the basic cellular pr...

journal_title：Seminars in cancer biology

authors： Gordeeva O

更新日期：2018-12-01 00:00:00

abstract：:Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins. ER stress triggers a conserved...

journal_title：Seminars in cancer biology

authors： González-Quiroz M,Urra H,Limia CM,Hetz C

更新日期：2018-06-01 00:00:00

abstract：:Tumor masses are deprived of oxygen and characterized by enhanced glucose uptake followed by glycolysis. Elevated glucose levels induce non-enzymatic glycosylation or glycation of proteins which leads to accumulation of advanced glycation end products (AGE). These AGE molecules bind to their respective receptors calle...

journal_title：Seminars in cancer biology

authors： Khan MI,Rath S,Adhami VM,Mukhtar H

更新日期：2018-04-01 00:00:00

abstract：:As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compar...

journal_title：Seminars in cancer biology

authors： Strickertsson JAB,Desler C,Rasmussen LJ

更新日期：2017-12-01 00:00:00

abstract：:Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestig...

journal_title：Seminars in cancer biology

authors： Kim HJ,Maiti P,Barrientos A

更新日期：2017-12-01 00:00:00

abstract：:Mitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes a...

journal_title：Seminars in cancer biology

authors： Simula L,Nazio F,Campello S

更新日期：2017-12-01 00:00:00

abstract：:Mitochondria are essential intracellular organelles that regulate energy metabolism, cell death, and signaling pathways that are important for cell proliferation and differentiation. Therefore, mitochondria are fundamentally implicated in cancer biology, including initiation, growth, metastasis, relapse, and acquired ...

journal_title：Seminars in cancer biology

authors： Kim HK,Noh YH,Nilius B,Ko KS,Rhee BD,Kim N,Han J

更新日期：2017-12-01 00:00:00

abstract：:Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting ...

journal_title：Seminars in cancer biology

authors： Braicu C,Mehterov N,Vladimirov B,Sarafian V,Nabavi SM,Atanasov AG,Berindan-Neagoe I

更新日期：2017-10-01 00:00:00

abstract：:Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides a crucial axis to support cell proliferation a...

journal_title：Seminars in cancer biology

authors： Huynh J,Etemadi N,Hollande F,Ernst M,Buchert M

更新日期：2017-08-01 00:00:00

abstract：:Exosomes are small membrane vesicles with a size ranging from 40 to 100nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes in...

journal_title：Seminars in cancer biology

authors： Steinbichler TB,Dudás J,Riechelmann H,Skvortsova II

更新日期：2017-06-01 00:00:00

abstract：:As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketoge...

journal_title：Seminars in cancer biology

authors： Schwartz L,Seyfried T,Alfarouk KO,Da Veiga Moreira J,Fais S

更新日期：2017-04-01 00:00:00

abstract：:While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we...

journal_title：Seminars in cancer biology

authors： Dumas JF,Brisson L,Chevalier S,Mahéo K,Fromont G,Moussata D,Besson P,Roger S

更新日期：2017-04-01 00:00:00

abstract：:Prostate cancer (PCa), a hormonally-driven cancer, ranks first in incidence and second in cancer related mortality in men in most Western industrialized countries. Androgen and androgen receptor (AR) are the dominant modulators of PCa growth. Over the last two decades multiple advancements in screening, treatment, sur...

journal_title：Seminars in cancer biology

authors： Kallifatidis G,Hoy JJ,Lokeshwar BL

更新日期：2016-10-01 00:00:00

abstract：:Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biologica...

journal_title：Seminars in cancer biology

authors： Spina V,Rossi D

更新日期：2016-08-01 00:00:00

abstract：:Diffuse large B cell lymphoma (DLBCL) is the most common form of B cell non-Hodgkin lymphoma worldwide and comprises a heterogeneous group of malignancies that originate from the malignant transformation of germinal center (GC) B cells. Over the past decade, significant improvement has been achieved in our understandi...

journal_title：Seminars in cancer biology

authors： Pasqualucci L,Zhang B

更新日期：2016-08-01 00:00:00

abstract：:Maintenance and accurate propagation of the genetic material are key features for physiological development and wellbeing. The replication licensing machinery is crucial for replication precision as it ensures that replication takes place once per cell cycle. Thus, the expression status of the components comprising th...

journal_title：Seminars in cancer biology

authors： Petrakis TG,Komseli ES,Papaioannou M,Vougas K,Polyzos A,Myrianthopoulos V,Mikros E,Trougakos IP,Thanos D,Branzei D,Townsend P,Gorgoulis VG

更新日期：2016-06-01 00:00:00

abstract：:Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (ove...

journal_title：Seminars in cancer biology

authors： Mantso T,Goussetis G,Franco R,Botaitis S,Pappa A,Panayiotidis M

更新日期：2016-06-01 00:00:00

abstract：:The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7...

journal_title：Seminars in cancer biology

authors： Wang H,Maitra A,Wang H

更新日期：2016-02-01 00:00:00

abstract：:Patients with HIV infection are at increased risk of developing non-Hodgkin lymphoma and Hodgkin lymphoma. While the pathogenesis of these lymphomas is incompletely understood, evidence indicates that immune deregulation, genetic alterations and cytokine production play an important role in HIV lymphomagenesis. The ly...

journal_title：Seminars in cancer biology

authors： Pantanowitz L,Carbone A,Dolcetti R

更新日期：2015-10-01 00:00:00

abstract：:Both the hexosamine biosynthetic pathway (HBP) and the endoplasmic reticulum (ER) are considered sensors for the nutritional state of the cell. The former is a branch of the glucose metabolic pathway that provides donor molecules for glycosylation processes, whereas the second requires co-translational N-glycosylation...

journal_title：Seminars in cancer biology

authors： Vasseur S,Manié SN

更新日期：2015-08-01 00:00:00

abstract：:DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy...

journal_title：Seminars in cancer biology

authors： Skvortsov S,Debbage P,Lukas P,Skvortsova I

更新日期：2015-04-01 00:00:00

abstract：:The 7th edition of the TNM defines multifocal breast cancer as multiple simultaneous ipsilateral and synchronous breast cancer lesions, provided they are macroscopically distinct and measurable using current traditional pathological and clinical tools. According to the College of American Pathologists (CAP), the chara...

journal_title：Seminars in cancer biology

authors： Salgado R,Aftimos P,Sotiriou C,Desmedt C

更新日期：2015-04-01 00:00:00

abstract：:Cathepsin X is a cysteine carboxypeptidase, localized predominantly in immune cells, regulating their proliferation, maturation, migration and adhesion. It has recently been confirmed as a significant promoter of malignant progression. Its role in signal transduction was first implied through the interaction with inte...

journal_title：Seminars in cancer biology

authors： Kos J,Vižin T,Fonović UP,Pišlar A

更新日期：2015-04-01 00:00:00

abstract：:Different types of RNAs identified thus far represent a diverse group of macromolecules that are involved in the regulation of different biological processes. RNA is generally thought to be localized primarily in the nucleus and cytoplasm; however, some types of RNA have been detected in the extracellular milieu. Thes...

journal_title：Seminars in cancer biology

authors： Redzic JS,Balaj L,van der Vos KE,Breakefield XO

更新日期：2014-10-01 00:00:00

abstract：:Malignant cancer cells do not act as lone wolves to achieve metastasis, as they exist within a complex ecosystem consisting of an extracellular matrix scaffold populated by carcinoma-associated fibroblasts (CAFs), endothelial cells and immune cells. We recognize local (primary tumor) and distant ecosystems (metastasis...

journal_title：Seminars in cancer biology

authors： De Wever O,Van Bockstal M,Mareel M,Hendrix A,Bracke M

更新日期：2014-04-01 00:00:00